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Study To Evaluate Safety, Drug

Interaction,Tumor Markers Of 

Axitinib In Combination With

Pembrolizumab (MK-3475) 

 Last updated: April 09, 2018
 STATUS: Ongoing but not recruiting (not accepting new patients) (per ClinicalTrials.gov/NCT02133742)


is the trial for?

Patients with kidney cancer (Renal cell carcinoma, RCC) who currently meet the following criteria:

  • predominantly clear cell histology
  • documented locally advanced or metastatic renal cell carcinoma
  • overall health status has to be good (ECOG 0 or 1)
  • controlled hypertension


is the key question that this trial is attempting to answer?

This phase-I study aims to evaluate the safety and tolerability of a new immuno-therapy in combination with a standard drug for RCC.

It investigates the PD-L1 inhibitor pemrolizumab (MK-3475) plus axitinib in patients with locally advanced or metastatic renal cell carcinoma (RCC).


patients might want to participate?

This clinical trial offers patients an opportunity to access a new therapy that may be effective for kidney cancer. This trial will support further research in kidney cancer and potentially help other patients with kidney cancer. The trial might or might not have benefit in your individual case. For more about the importance and benefits of joining clinical trials, please click here.


will the trial be open?

The study is not recruiting any more – approx. 60 patients are currently participating.


is the trial available?

The trial will be available in 18 cancer centres in the USA.
For a complete list of trial locations, please click here:
 pdf Trial Locations MK-3475+axitinib (303 KB)



What does the study look like?

There will be one study arm (group): all participating patients will be assigned axitinib (Inlyta) in combination with pembrolizumab (Keytruda™, MK 3475).

Pembolizumab will be given intravenously every three weeks plus axitinib orally once a day.


do I get more information?

Patient organisations supporting kidney cancer patients in your country may offer additional information about the trial, current recruitment status, and key contacts. Click here for a list of patient organisations serving kidney cancer patients. If there are no such organisations in your country, please email us for more information: This email address is being protected from spambots. You need JavaScript enabled to view it.


with other patients on this trial

If you want to connect with other patients considering or participating in this trial, you can find them here: List of organisations worldwide.


your experience 

You want to share your experience on this trial?
Send us an e-mail to: This email address is being protected from spambots. You need JavaScript enabled to view it.
Note that your experience would be helpful for other patients and patient organisations.


of the study

No results are available at this time. Future results will be linked here.
Disclaimer: This is a patient-friendly summary of the clinical trial which has been provided for informational purposes only. Patients should consult their physician about any clinical trial opportunity.
Back to clinical trials overview: How can I find an IO clinical trial for my cancer?